Senior In-Vivo Scientist – Microbiologist

PARIS, FRANCE          FULL TIME

— About Eligo —

Eligo Bioscience, backed by top-tier investors from Silicon Valley and Europe, is pioneering next-generation microbiome therapeutics. Co-founded by MIT and Rockefeller University scientists, Eligo is headquartered in Paris, France. Our mission is to address unmet medical needs in inflammatory and infectious diseases, as well as oncology, through groundbreaking gene-editing medicines.

Our first-in-class synthetic biology platform has earned Eligo numerous international awards and recognition, including being named one of the World Economic Forum’s “30 Most Innovative Companies” and has been featured in international press Nature, Science, The Economist, BBC, The New York Times, etc.

More recently, our latest work pas published in Nature this summer (In situ targeted base editing of bacteria in the mouse gut)

— Organization Context // Why Join Us? —

With over $50M in funding (including a recent $35M Series B), we’re well-positioned for our next major milestones: advancing our first drug in clinical trials by 2026, progressing a stealth project with a Top-10 Pharma partner, and exploring new applications for our technology.

Our team of 30+ “Eligonauts” is deeply invested in pushing scientific boundaries within a vibrant, collaborative culture. We embrace diversity, equal opportunity and inclusion and are committed to building diverse teams in a fast-paced environment fostering scientific excellence and benevolence.

— The role —

As part of the Host-Microbiome interactions team, you will both contribute to the generation of pivotal preclinical data to support the development of Eligo’s programs towards the clinic, and to discovery work supporting the entry of new programs into Eligo portfolio.

You will join a team of translational scientists with strong experience in the set up and execution of in vitro, ex vivo and in vivo models across various fields (immunology, microbiology, molecular biology, pharmacology) to support the preclinical development of Eligo’s programs either internally or in collaboration with external partners. You will report to the Senior Director of Host-Microbiome interactions.

— Key Responsibilities —

• Design, execute, and oversee hands-on experiments across in vivo (rodents), ex vivo (human or rodent primary cells and tissues), and in vitro (cell lines, bacterial cultures) models, employing diverse cellular biology, immunology, microbiology, and molecular biology techniques.
• Analyze, interpret, and effectively communicate experimental findings at various meetings involving multidisciplinary teams and/or collaborators.
• Independently plan experimental paths forward, proactively develop and/or optimize methods, and incorporate new technology/techniques into practice.
• Prepare comprehensive reports and presentation materials as necessary, and maintain meticulous experimental documentation in electronic lab notebooks in accordance with Eligo’s working practice.
• Contribute to scientific review meetings and assist in drafting relevant sections of regulatory documents as needed.
• Foster a collaborative and supportive environment, aiding in the development and well-being of fellow team members while also participating in general lab support operations.
• Stay aware of recent advancements in the field through literature review and dissemination of data via presentations at scientific conferences when relevant.

— Qualifications —

Technical skills

• PhD in Biology, Immunology, Microbiology, or related fields with a track record of publications
• Extensive experience in rodent models of host-pathogen or host-microbiome interactions
• Regulatory Animal training up to date (study design and/or execution)
• Postdoctoral training or previous drug discovery or development experience in a biotech or pharmaceutical company setting is highly advantageous.
• Hands-on experience in models of bacterial colonization of the intestine or the skin is highly advantageous.
• Hands on experience with models involving Clostridia species is advantageous
• Experience with digital droplet PCR (ddPCR) is advantageous
• Ability to design and run experiments, interpret data, troubleshoot, suggest next steps and identify alternative approaches.
• Ability to deliver high-quality, consistent results in a timely fashion.
• Experience in immunological and molecular biology techniques including but not limited to flow cytometry, nucleic acid extraction, qPCR/ddPCR, ELISA, Western Blotting. Proficiency in utilizing functional genomic editing tools (CRISPR-Cas, si/hRNA) is advantageous.

Other skills

• Self-motivated, creative and critical thinker with a ‘can-do’ attitude eager to contribute to the development of novel therapeutics
• Independent, proactive, and with a strong sense of accountability.
• Flexible, adaptable, open to new ideas and able to function under pressure.
• Meticulous, rigorous, result-oriented and committed to scientific integrity and ethics
• Outstanding organization skills, time management, and able to prioritize tasks across multiple projects in a fast-paced environment.
• Effective team player with excellent interpersonal skills
• Experience in managing relationships with external collaborators is advantageous

— Benefits —

— Additional perks —